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European Veterinary Renal Pathology Service: A Survey Over a 7-Year Period (2008-2015)
L Aresu1, V Martini2, S L Benali3
1Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis Legnaro, PD, Italy.
Journal of Veterinary Internal Medicine
|August 2, 2017
Summary
Canine kidney disease presentation varies by pathological findings. Immune-complex-mediated glomerulonephritis (ICGN) dogs show lower albumin and higher protein loss, but differentiation is challenging.
Area of Science:
- Veterinary Pathology
- Canine Nephrology
- Renal Biopsy Analysis
Background:
- The European Veterinary Renal Pathology Service (EVRPS) established the first European web-based registry for canine renal biopsy specimens.
- This study leverages EVRPS data to investigate canine nephropathy.
Purpose of the Study:
- To determine if clinical and laboratory findings in dogs with nephropathy correlate with specific renal pathological diagnoses.
- To explore differences in presentation based on light and electron microscopy findings.
Main Methods:
- Analysis of 162 canine renal biopsy specimens from the EVRPS archive with available light and electron microscopy.
- Classification of specimens into immune-complex-mediated glomerulonephritis (ICGN), non-immune-complex-mediated GN (non-ICGN), and renal lesions not otherwise specified (RL-NOS).
- Investigation of clinical and laboratory variables across different morphological diagnoses and disease categories.
Main Results:
- Dogs with ICGN exhibited significantly lower serum albumin and higher urine protein-to-creatinine ratio (UPC) compared to non-ICGN and RL-NOS groups.
- Specific morphological diagnoses like amyloidosis and membranous glomerulonephritis were associated with lower albumin levels.
- Membranoproliferative glomerulonephritis (MPGN) cases showed higher UPC than focal and segmental glomerulosclerosis (FSGS) subtypes.
Conclusions:
- Immune-complex-mediated glomerulonephritis (ICGN), particularly MPGN, is linked to substantial protein loss and hypoalbuminemia in dogs.
- Clinical and laboratory data alone present challenges in differentiating specific morphological diagnoses and disease categories due to overlapping results.
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