Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

1.5K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
1.5K
Bulimia Nervosa01:30

Bulimia Nervosa

865
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
865
Binge Eating Disorders01:23

Binge Eating Disorders

563
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
563
Regional Terms01:12

Regional Terms

16.4K
Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
16.4K
Self-Discrepancy Theory02:45

Self-Discrepancy Theory

19.0K
One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.  
19.0K
Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

11.2K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computed tomography-based prediction of commissural positions facilitates valve-sparing aortic root replacement.

JTCVS techniques·2026
Same author

Concurrent Pituitary and Thyroid Immune-Related Adverse Events after Immune Checkpoint Inhibitors Associated with HLA-DR15-Related Haplotypes.

Cancer immunology research·2026
Same author

Incidence of right heart failure and its impact on survival outcomes after implantable left ventricular assist device implantation.

Heart and vessels·2026
Same author

Strategic Transcatheter Aortic Valve Replacement in Patients With Protruding Left Coronary Artery Stents.

JACC. Case reports·2026
Same author

Orthotopic heart transplantation for Fontan failure: experience and treatment strategy-a case report.

General thoracic and cardiovascular surgery cases·2026
Same author

Comparison of left bundle branch area pacing and biventricular pacing for atrioventricular block with heart failure and mild-to-moderately reduced left ventricular systolic function: design and rationale of the BLOCK NAGOYA randomized clinical trial.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026

Related Experiment Video

Updated: Feb 25, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

78.1K

Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa.

Kunihiro Kohmura1, Yasunori Adachi2, Satoshi Tanaka3

  • 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Seichiryo Hospital, Nagoya, Aichi, Japan.

Psychiatry Research. Neuroimaging
|August 2, 2017
PubMed
Summary

Brain imaging reveals reduced gray matter volume (GMV) in anorexia nervosa (AN) patients, particularly in the superior temporal gyrus (STG), linked to body dissatisfaction. These findings offer insights into AN pathophysiology.

More Related Videos

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

13.2K
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K

Related Experiment Videos

Last Updated: Feb 25, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

78.1K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

13.2K
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Anorexia nervosa (AN) is a complex psychiatric disorder with poor prognosis for some, and its causes and effective treatments remain unclear.
  • Understanding the neural underpinnings of AN is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate brain morphometric changes in individuals with anorexia nervosa.
  • To explore the association between these brain changes and specific AN symptoms, such as body dissatisfaction.

Main Methods:

  • Utilized T1-weighted magnetic resonance imaging (MRI) on 52 participants (AN subtypes and healthy controls).
  • Employed voxel-based morphometry (VBM) to analyze group differences in gray matter volume (GMV), controlling for age and body mass index (BMI).
  • Examined correlations between regional GMV and psychological measures like drive for thinness and body dissatisfaction.

Main Results:

  • Patients with AN showed decreased GMV in the superior/middle temporal gyrus (STG/MTG), pulvinar, and superior frontal gyrus compared to controls, after adjusting for age and BMI.
  • Further analysis revealed decreased GMV in the STG/MTG, middle frontal gyrus, and cingulate, adjusting for age.
  • A significant correlation was found between body dissatisfaction and GMV in the STG.

Conclusions:

  • Reduced GMV in the STG may be associated with body dissatisfaction in AN, potentially linked to impaired visuospatial perception.
  • Observed GMV reductions in multiple brain regions suggest their involvement in the development and pathophysiology of anorexia nervosa.
  • These findings highlight potential neurobiological targets for future AN research and treatment strategies.