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Related Concept Videos

Tissues01:18

Tissues

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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

Tissues

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Plant Cells and Tissues02:01

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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Plant Tissue Culture02:57

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Plant tissue culture is widely used in both primary and applied science. Applications range from plant development studies to functional gene studies, crop improvement, commercial micropropagation, virus elimination, and conservation of rare species.
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Tissue Membranes01:27

Tissue Membranes

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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
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Plant Tissues01:18

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Plants are multicellular eukaryotes with tissue systems made of various cell types that carry out specific functions. Different tissues work together to perform a unique function and form an organ. Organs working together form organ systems. Vascular plants have two distinct organ systems: a shoot system and a root system. The shoot system consists of two portions: the vegetative (non-reproductive) parts of the plant, such as the leaves and the stems, and the reproductive parts of the plant,...
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Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues
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Deciphering adipose tissue heterogeneity.

Matthew D Lynes1, Yu-Hua Tseng1

  • 1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts.

Annals of the New York Academy of Sciences
|August 2, 2017
PubMed
Summary
This summary is machine-generated.

Obesity, an excess of adipose tissue, is a major health crisis. Understanding adipose tissue heterogeneity is key to developing personalized treatments for obesity and related conditions like type II diabetes.

Keywords:
adipocyteadipose tissuecellular heterogeneitypreadipocyte

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Area of Science:

  • Metabolic science
  • Cell biology
  • Human physiology

Background:

  • Obesity, characterized by excess adipose tissue, poses significant health risks, including type II diabetes and metabolic syndrome.
  • The complex heterogeneity of human adipose tissue leads to varied responses to energy imbalance and treatments.
  • Individual variability in obesity development is influenced by genetics, environment, sex, and adipose tissue characteristics.

Purpose of the Study:

  • To explore the heterogeneity of adipose tissue.
  • To understand the role of distinct cell populations within different fat depots in energy homeostasis.
  • To investigate adipogenic differentiation and lipid accumulation transcriptional programs.

Main Methods:

  • Describing distinct cell populations in various fat depots.
  • Investigating adipogenic differentiation processes.
  • Analyzing transcriptional programs of lipid accumulation.

Main Results:

  • Adipose tissue exhibits significant heterogeneity in cell types and functions across different depots.
  • Variations in cell populations and their functions contribute to individual metabolic status.
  • Understanding cell- and depot-specific functions is crucial for interpreting energy excess impacts.

Conclusions:

  • A precision medicine approach is needed for obesity due to individual variability.
  • Characterizing adipose tissue heterogeneity can elucidate its role in whole-body energy homeostasis.
  • Further research into adipose tissue biology can inform personalized metabolic health strategies.