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2-methoxyethylacrylate modified polysulfone membrane and its blood compatibility
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
Archives of Biochemistry and Biophysics
|August 3, 2017
Summary
Grafting 2-methoxyethylacrylate (MEA) onto polysulfone (PSF) membranes enhances hydrophilicity and significantly improves blood compatibility. This modification is crucial for advanced biomaterial applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Modification
Background:
- Polysulfone (PSF) membranes are widely used but often exhibit poor blood compatibility.
- Enhancing the hydrophilicity of biomaterials is critical for reducing adverse biological responses.
Purpose of the Study:
- To graft 2-methoxyethylacrylate (MEA) onto PSF membranes to improve their surface properties.
- To evaluate the impact of MEA grafting on the hydrophilicity and blood compatibility of PSF membranes.
Main Methods:
- Surface grafting of MEA onto PSF membranes using Michael addition reaction.
- Characterization of modified membranes using 1H NMR, ATR-FTIR, and XPS.
- Assessment of hydrophilicity via water contact angle measurements.
- Evaluation of blood compatibility through protein adsorption, platelet adhesion, and coagulation time tests (PT, APTT, TT).
Main Results:
- Successful grafting of MEA onto the PSF membrane surface was confirmed by spectroscopic techniques.
- Water contact angle decreased from 76° to 59.5°, indicating enhanced hydrophilicity.
- Modified membranes showed improved blood compatibility, with reduced protein adsorption and platelet adhesion, and normalized coagulation times.
Conclusions:
- The grafting of MEA onto PSF membranes effectively enhances hydrophilicity.
- MEA grafting significantly improves the blood compatibility of PSF membranes, making them promising for biomedical applications.
