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Published on: August 20, 2014
2-methoxyethylacrylate modified polysulfone membrane and its blood compatibility
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
Abstract:
Hydrophilic material 2-methoxyethylacrylate (MEA) was grafted onto polysulfone (PSF) membrane via Michael addition reaction. The 1H nuclear magnetic resonance (1H NMR), Attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) characterization of the modified membrane proved that MEA had been successfully grafted onto PSF membrane surface. The water contact angle of the membrane surface was tested. The results showed that the water contact angle changed from 76° to 59.5°, which means that the hydrophilicity of the modified membrane was improved. A series of blood compatibility tests including bovine serum protein adsorption, platelet adhesion, prothrombin time (PT), partial thromboplastin time (APTT) and thrombin time (TT) were carried out on PSF membrane and the modified PSF membrane with highest grafted density of MEA. All of the results indicate that MEA plays an important role in improving the blood compatibility of PSF membrane.
Insights
Grafting 2-methoxyethylacrylate (MEA) onto polysulfone (PSF) membranes enhances hydrophilicity and significantly improves blood compatibility. This modification is crucial for advanced biomaterial applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Modification
Background:
- Polysulfone (PSF) membranes are widely used but often exhibit poor blood compatibility.
- Enhancing the hydrophilicity of biomaterials is critical for reducing adverse biological responses.
Purpose of the Study:
- To graft 2-methoxyethylacrylate (MEA) onto PSF membranes to improve their surface properties.
- To evaluate the impact of MEA grafting on the hydrophilicity and blood compatibility of PSF membranes.
Main Methods:
- Surface grafting of MEA onto PSF membranes using Michael addition reaction.
- Characterization of modified membranes using 1H NMR, ATR-FTIR, and XPS.
- Assessment of hydrophilicity via water contact angle measurements.
- Evaluation of blood compatibility through protein adsorption, platelet adhesion, and coagulation time tests (PT, APTT, TT).
Main Results:
- Successful grafting of MEA onto the PSF membrane surface was confirmed by spectroscopic techniques.
- Water contact angle decreased from 76° to 59.5°, indicating enhanced hydrophilicity.
- Modified membranes showed improved blood compatibility, with reduced protein adsorption and platelet adhesion, and normalized coagulation times.
Conclusions:
- The grafting of MEA onto PSF membranes effectively enhances hydrophilicity.
- MEA grafting significantly improves the blood compatibility of PSF membranes, making them promising for biomedical applications.
