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Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Published on: June 2, 2023

KRAB zinc finger proteins.

Gabriela Ecco¹, Michael Imbeault¹, Didier Trono²

¹School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Station19, 1015 Lausanne, Switzerland.

Development (Cambridge, England)

|August 3, 2017

Summary

Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are key regulators that silence transposable elements. New research shows these proteins also shape species-specific gene regulation and influence development.

Keywords:

Co-option Endovirome Gene regulation KRAB-ZFP Speciation Transposable element

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Area of Science:

Genomics
Molecular Biology
Evolutionary Biology

Background:

Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) form the largest transcriptional regulator family in vertebrates.
They utilize a KRAB domain and zinc finger array to bind DNA and, with KAP1 (TRIM28), repress transposable elements (TEs).

Purpose of the Study:

To provide an overview of the KRAB-ZFP gene family.
To highlight the evolutionary interplay between KRAB-ZFPs and TEs.
To explore the role of KRAB-ZFPs in development and physiology.

Main Methods:

Review of existing literature on KRAB-ZFPs and transposable elements.
Analysis of evolutionary relationships and functional roles.

Main Results:

KRAB-ZFPs and their TE targets collaborate to establish species-specific regulatory networks.
The evolutionary history of KRAB-ZFPs is intrinsically linked to that of TEs.
KRAB-ZFPs impact diverse developmental and physiological processes.

Conclusions:

KRAB-ZFPs are more than just a defense against TEs; they are crucial for establishing novel regulatory functions.
Understanding KRAB-ZFP evolution provides insights into genome evolution and organismal complexity.