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Updated: Feb 25, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Malignancy in Pediatric-onset Systemic Lupus Erythematosus.
Sasha Bernatsky1,2, Ann E Clarke3,4, Omid Zahedi Niaki3,4
1From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; University of Manitoba, Winnipeg, Manitoba; University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Duke University Medical Center, Durham, North Carolina; Seattle Children's Hospital, Seattle, Washington; Columbia University Medical Center, New York, New York; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Hackensack University Medical Center, Hackensack, New Jersey; University of Alabama at Birmingham, Birmingham, Alabama; University of Chicago; Northwestern University Feinberg School of Medicine, Chicago, Illinois; Riley Hospital for Children, Indianapolis, Indiana; University of California, San Francisco, San Francisco, California, USA. sasha.bernatsky@mcgill.ca.
Pediatric systemic lupus erythematosus (SLE) patients show an increased cancer incidence, particularly hematologic cancers like lymphoma. Further research is needed to understand risk factors in this population.
Area of Science:
- Pediatric Rheumatology
- Oncology
- Epidemiology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Pediatric-onset SLE (pSLE) presents unique challenges and potential long-term health risks.
- Cancer incidence in pSLE is not well-established.
Purpose of the Study:
- To determine the incidence of cancer in a large cohort of patients with pediatric-onset SLE.
- To identify specific cancer types and compare observed rates to expected rates in the general population.
Main Methods:
- Utilized data from 12 North American pediatric SLE registries.
- Linked patient data to regional cancer registries for cancer detection post-cohort entry.
- Calculated standardized incidence ratios (SIR) to compare observed to expected cancer rates.
Main Results:
- Identified 1168 patients with a mean follow-up of 7.6 years.
- Observed 14 invasive cancers, yielding an overall SIR of 4.13.
- Hematologic cancers, primarily lymphomas, showed an elevated SIR of 4.68.
Conclusions:
- Cancer is a rare but increased outcome in pediatric-onset SLE patients.
- Hematologic malignancies represent a significant proportion of cancers in this cohort.
- Longer follow-up and investigation into drug effects and disease activity are recommended.
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