Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Towards the construction of a virtual yeast.

Nature·2026

Same author

Bronchial mucosal nuclear transcription factor expression and inflammatory response in humans after exposure to wood smoke.

Particle and fibre toxicology·2026

Same author

Sleep apnoea in patients undergoing colorectal cancer surgery: prospective cohort study.

BJS open·2026

Same author

Economic evaluation of long-term oxygen therapy: 24 hours versus 15 hours per day in severe hypoxemia-the REDOX trial.

Annals of the American Thoracic Society·2026

Same author

The adaptive molecular landscape of reprogrammed telomeric sequences.

Nature communications·2026

Same author

No association between troponin and COPD without cardiovascular influence: findings from a population-based cohort (SCAPIS).

Thorax·2026

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Budding Yeast Strains and Genotype-Phenotype Mapping.

Gianni Liti¹, Jonas Warringer^2,3, Anders Blomberg⁴

¹IRCAN, CNRS UMR 6267, INSERM U998, University of Nice, 06107 Nice, France.

Cold Spring Harbor Protocols

|August 3, 2017

Summary

Common laboratory yeast strains, like S288C, limit understanding of Saccharomyces cerevisiae biology. Utilizing natural genetic variation is crucial for a comprehensive genotype-phenotype map in yeast research.

More Related Videos

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Published on: March 24, 2010

BEST: Barcode Enabled Sequencing of Tetrads

BEST: Barcode Enabled Sequencing of Tetrads

Published on: May 1, 2014

Related Experiment Videos

Last Updated: Feb 25, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Published on: March 24, 2010

BEST: Barcode Enabled Sequencing of Tetrads

BEST: Barcode Enabled Sequencing of Tetrads

Published on: May 1, 2014

Area of Science:

Microbiology
Genetics
Yeast Biology

Background:

Laboratory strains of Saccharomyces cerevisiae, primarily S288C, are widely used in research.
These strains may not fully represent the phenotypic diversity or genetic complexity of wild yeast populations.
Multilocus phenotypes in lab strains may not reflect natural selection or environmental adaptation.

Purpose of the Study:

To highlight the limitations of current laboratory yeast strains for comprehensive biological studies.
To emphasize the need for incorporating natural genetic variation into yeast research.
To discuss methodologies for creating a complete genotype-phenotype map using natural yeast diversity.

Main Methods:

Reviewing existing literature on Saccharomyces cerevisiae laboratory strains.
Analyzing the genetic diversity of natural yeast populations through isolation and sequencing.
Discussing approaches for integrating natural variation into genotype-phenotype mapping.

Main Results:

Laboratory strains, often derived from S288C, offer limited insight into the full spectrum of S. cerevisiae biology.
Natural yeast populations exhibit greater sequence diversity than commonly used lab strains.
Current lab strains do not capture the evolutionary context of multilocus phenotypes.

Conclusions:

A broader sampling of natural genetic variation is essential for a complete understanding of yeast biology.
Methodologies are needed to leverage natural yeast diversity for accurate genotype-phenotype mapping.
Future research should focus on incorporating wild strains to overcome limitations of lab-evolved strains.