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[Multiple endocrine adenomatosis manifested chiefly by hyperparathyroidism].

S Nachev, I Mikhaĭlov, S Donev

    Vutreshni Bolesti
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    This case report details a patient with multiple endocrine neoplasia, presenting with parathyroid adenoma causing hypercalcemia and widespread metastases. Early diagnosis is crucial for potential surgical intervention and patient survival.

    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Multiple Endocrine Neoplasia (MEN) syndromes involve inherited genetic predispositions leading to tumors in endocrine glands.
    • Parathyroid adenomas are common endocrine tumors, often causing hypercalcemia due to excessive parathyroid hormone production.

    Observation:

    • A patient presented with a parathyroid adenoma, pancreatic adenomas (A-cell type), and an adrenal adenoma.
    • The parathyroid adenoma's hyperfunction resulted in severe hypercalcemia (3.75 mmol/l).
    • Necropsy revealed extensive calcium metastases in the lungs, kidneys, and heart.

    Findings:

    • The patient's death was attributed to advanced ischemic heart disease, complicated by chronic pyelonephritis and renal insufficiency.
    • Histological and electron microscopic examination confirmed the nature of the pancreatic and adrenal adenomas.

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    Implications:

    • This case underscores the importance of recognizing and diagnosing multiple endocrine neoplasia syndromes.
    • Timely diagnosis and surgical intervention for endocrine tumors can potentially improve patient outcomes and survival.
    • Understanding the link between endocrine hyperfunction and metastatic calcification is vital for clinical management.