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Aortic Flow Propagation Velocity in Patients with Familial Mediterranean Fever: an Observational Study

Kayihan Karaman1, Arif Arisoy1, Aysegul Altunkas2

  • 1Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

Korean Circulation Journal
|August 3, 2017
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) patients show lower aortic flow propagation velocity (APV), an indicator of arterial stiffness. This study suggests APV may predict FMF and is linked to carotid intima-media thickness (CIMT).

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic inflammation is implicated in atherosclerosis and arterial stiffness (AS).
  • Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease.
  • The link between systemic inflammation in FMF and AS is not well-established.

Purpose of the Study:

  • To investigate early markers of arterial stiffness (AS) in patients with Familial Mediterranean Fever (FMF).
  • To assess the relationship between systemic inflammation and AS in FMF patients.
  • To measure aortic flow propagation velocity (APV) and carotid intima-media thickness (CIMT) in FMF patients.

Main Methods:

  • Sixty-one FMF patients and 57 healthy controls were studied during an attack-free period.
  • Individuals with known atherosclerotic risk factors were excluded.
  • Aortic flow propagation velocity (APV) and carotid intima-media thickness (CIMT) were measured to assess arterial stiffness (AS).

Main Results:

  • FMF patients exhibited significantly lower APV and higher CIMT compared to controls.
  • APV correlated negatively with CIMT and erythrocyte sedimentation rate (ESR).
  • APV and ESR were independent predictors of FMF; CIMT and left ventricle ejection fraction (LVEF) were associated with APV.

Conclusions:

  • Aortic flow propagation velocity (APV) is reduced in Familial Mediterranean Fever (FMF) patients.
  • APV is related to carotid intima-media thickness (CIMT), suggesting increased arterial stiffness in FMF.
  • APV may serve as an independent predictor for FMF.
Keywords:
Aortic flow propagation velocityArterial stiffnessCarotid intima-media thicknessFamilial Mediterranean fever

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