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Updated: Feb 25, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis.

Cyril Atkinson-Clement¹, Serge Pinto^1,2, Alexandre Eusebio^3,4

¹Aix Marseille Univ, CNRS, LPL, Aix-en-Provence, France.

Neuroimage. Clinical

|August 3, 2017

Summary

Diffusion tensor imaging (DTI) effectively distinguishes Parkinson's disease (PD) patients from controls by revealing brain tissue degeneration. This meta-analysis highlights DTI's sensitivity in studying PD pathophysiology and severity.

Keywords:

Diffusion tensor imaging Fractional anisotropy Idiopathic Parkinson's disease Mean diffusivity Neuroimaging

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Area of Science:

Neuroimaging
Neurology
Biomedical Engineering

Background:

Parkinson's disease (PD) pathophysiology and symptoms are studied using neuroimaging.
Diffusion Tensor Imaging (DTI) investigates structural brain changes in PD.
A comprehensive whole-brain meta-analysis of DTI in PD was previously lacking.

Purpose of the Study:

To conduct a whole-brain meta-analysis of DTI studies in Parkinson's disease.
To assess the utility of DTI metrics (FA and MD) in differentiating PD patients from healthy controls.
To explore associations between DTI findings and clinical/MRI parameters.

Main Methods:

Meta-analysis of 39 studies including 1855 participants (1087 PD, 768 controls).
Analysis of fractional anisotropy (FA) and mean diffusivity (MD) effect sizes (D_ES).
Regions of interest classified anatomically; statistical analysis included heterogeneity (I²) and correlations with co-variables.

Main Results:

FA-D_ES and MD-D_ES successfully distinguished PD patients from controls.
Significant degenerations detected in substantia nigra, corpus callosum, cingulate, and temporal cortices.
MD-D_ES showed sensitivity to DTI acquisition parameters (e.g., echo time) and clinical factors.

Conclusions:

DTI is a sensitive neuroimaging technique for studying PD pathophysiology and severity.
DTI findings indicate widespread brain degeneration in PD, including some opposing changes.
Combining DTI with other MRI methods may enhance the study of brain degeneration in PD.