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Related Experiment Videos

The diabetic brain and cognition.

Peter Riederer1, Amos D Korczyn2, Sameh S Ali3

  • 1Center of Mental Health, Department Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, 97080, Würzburg, Germany. peter.riederer@mail.uni-wuerzburg.de.

Journal of Neural Transmission (Vienna, Austria : 1996)
|August 3, 2017
PubMed

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Summary
This summary is machine-generated.

Type 2 diabetes (T2DM) significantly increases the risk for Alzheimer's disease (AD) and vascular dementia (VaD) due to impaired glucose utilization and brain insulin resistance. Early metabolic screening is crucial for dementia prevention and management.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Rising prevalence of Alzheimer's disease (AD) and vascular dementia (VaD) in aging populations.
  • Established link between diabetes and increased risk of cognitive impairment and dementia.

Purpose of the Study:

  • To elucidate the role of Type 2 Diabetes Mellitus (T2DM) in the pathogenesis of AD and VaD.
  • To review the impact of T2DM and brain insulin resistance on cognitive decline.

Main Methods:

  • Consensus review based on clinical and experimental data from international scientists.
  • Comprehensive literature search utilizing PUBMED database.

Main Results:

  • T2DM is confirmed as a significant risk factor for both AD and VaD.
Keywords:
Alzheimer’s diseaseCognitionDiabetes mellitusDiabetic brainEpidemiology of dementive disordersExperimental model of dementiaImaging in dementiaInsulin resistanceNeurogenesis in dementiaNeurotransmitters in dementiaPathology of dementiaVascular dementia

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  • Pathology involves disturbed glucose utilization and brain insulin resistance (IRBS).
  • T2DM and IRBS contribute to cerebrovascular disturbances in both dementia types.

    • Conclusions:

    • T2DM and the resulting insulin-resistant brain state are implicated in AD and VaD.
    • Early diagnosis of metabolic parameters, including T2DM, is essential.
    • Potential for diabetes therapeutics to influence dementia risk warrants further investigation.