Pathological lesions in mice infected with Thogoto virus, a tick-borne orthomyxovirus

The RNA structure of tick-borne Thogoto virus was found very closely related to that of the Orthomyxovividae family. Pathological lesions in the lungs, liver and intestine of white mice inoculated with Thogoto virus resemble to those described for influenza virus, however, an important differential characteristic is the high hepatotropism of Thogoto virus. Thogoto virus infection in the liver of mice seems suitable for the study of virus-induced necrotic lesions.