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Moisture resistant and biofriendly CD-MOF nanoparticles obtained via cholesterol shielding
Vikramjeet Singh1, Tao Guo, Haitong Xu
1Center for Drug Delivery System, Shanghai Institute of Materia Medica, 201210, Shanghai, China. jwzhang@simm.ac.cn.
Chemical Communications (Cambridge, England)
|August 3, 2017
Abstract:
A facile and one step-method was developed to enhance the water stability of CD-MOF nanoparticles through surface modification with cholesterol. CD-MOFs were able to maintain their cubic crystalline structures even after 24 h of incubation, well tolerated in vivo and could increase up to 4 times the blood half-life of DOX.
