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AxTract: Toward microstructure informed tractography.

Gabriel Girard1,2,3, Alessandro Daducci3,4,5, Laurent Petit6

  • 1Sherbrooke Connectivity Imaging Lab, Computer Science Department, Faculty of Science, Université de Sherbrooke, Sherbrooke, Canada.

Human Brain Mapping
|August 3, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces AxTract, a new diffusion-weighted MRI tractography method. AxTract improves white matter fascicle reconstruction by using microstructure information, reducing errors in complex brain regions.

Keywords:
ActiveAxaxon diameter indexdiffusion MRImicrostructuremulti-shell acquisitionwhite matter tractography

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Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Biophysics

Background:

  • Diffusion-weighted (DW) MRI tractography is crucial for in vivo human brain white matter analysis.
  • Current tractography methods generate numerous false positives due to complex tissue configurations.
  • The link between tractography streamlines and white matter microstructure is not well understood.

Purpose of the Study:

  • To develop a novel approach for simultaneous white matter fascicle reconstruction and axon diameter distribution characterization.
  • To leverage advanced DW-MRI microstructure acquisition, modeling, and reconstruction techniques.
  • To reduce tractography ambiguities in complex white matter areas.

Main Methods:

  • Introduced AxTract, a method utilizing DW-MRI microstructure data.
  • AxTract separates parallel fascicles based on distinct microstructure characteristics.
  • Evaluated AxTract on simulated data and 34 healthy subjects.

Main Results:

  • AxTract demonstrated a reduction in erroneous streamlines compared to conventional deterministic tractography on simulated data.
  • An average increase in streamline density was observed across 15 known fascicles in healthy subjects.
  • Microstructure information was shown to enhance tractography in white matter crossing areas.

Conclusions:

  • AxTract successfully distinguishes and tracks white matter fascicles using their microstructure characteristics.
  • The method offers new insights into white matter organization and quantitative brain connectivity.
  • AxTract represents a significant advancement in microstructure-informed tractography for complex white matter configurations.