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Association between hemorrhoid and risk of coronary heart disease: A nationwide population-based cohort study

Shih-Sheng Chang1, Fung-Chang Sung, Cheng-Li Lin

  • 1Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital Graduate Institute of Clinical Medical Science, China Medical University Management Office for Health Data, China Medical University Hospital Department of Health Services Administration School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

Medicine
|August 3, 2017
PubMed

Insights

Hemorrhoid patients face a significantly higher risk of developing coronary heart disease (CHD). This study found a 1.27-fold increased risk, highlighting a crucial link between hemorrhoids and cardiovascular health.

Area of Science:

  • Cardiovascular Epidemiology
  • Gastroenterology

Background:

  • Hemorrhoids are a common condition with potential systemic implications.
  • The association between hemorrhoids and coronary heart disease (CHD) risk requires further investigation.

Purpose of the Study:

  • To investigate the association between hemorrhoid diagnosis and the subsequent risk of developing coronary heart disease (CHD).

Main Methods:

  • A retrospective cohort study utilizing Taiwan's Longitudinal Health Insurance Database 2000.
  • Inclusion of 33,034 patients with hemorrhoids and 132,136 matched controls from 2000-2010.
  • Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).

Main Results:

  • Hemorrhoid patients exhibited a 1.36-fold higher incidence rate of CHD compared to controls (9.91 vs. 7.28 per 1000 person-years).
  • An adjusted hazard ratio (aHR) of 1.27 (95% CI: 1.21-1.34) indicated a significantly increased CHD risk in the hemorrhoid cohort.
  • The presence of comorbidities amplified CHD risk: 2 comorbidities (HR=7.12) and 1 comorbidity (HR=3.23) showed substantially elevated risks.

Conclusions:

  • Hemorrhoid patients demonstrate a statistically significant increased risk of coronary heart disease development.
  • The findings underscore the importance of considering cardiovascular risk in patients diagnosed with hemorrhoids, particularly those with comorbidities.

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