Burning Fat and Building Bone by FSH Blockade.
Carlos Henrique Sponton1, Shingo Kajimura2
1Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA; Obesity and Comorbidities Research Center-OCRC, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
Cell Metabolism
|August 3, 2017
Summary
Blocking follicle-stimulating hormone (FSH) action can reduce body fat by enhancing brown fat activity. This discovery offers a potential new treatment for metabolic diseases linked to menopause.
Area of Science:
- Endocrinology
- Metabolic Science
- Reproductive Biology
Background:
- Elevated follicle-stimulating hormone (FSH) levels are characteristic of menopause.
- Menopause-related FSH increase is associated with osteoporosis and increased visceral fat.
- Metabolic disturbances are common during menopause.
Purpose of the Study:
- To investigate the role of FSH in regulating body fat.
- To explore the potential of targeting FSH for treating menopause-related metabolic conditions.
Main Methods:
- The study investigated the effects of blocking FSH action in a relevant biological model.
- Researchers examined the impact on brown and beige adipose tissue thermogenesis.
Main Results:
- Blocking FSH action led to a reduction in body fat.
- This reduction was associated with increased thermogenesis in brown and beige fat.
- FSH blockade demonstrates a direct link to fat mass regulation.
Conclusions:
- Targeting FSH action presents a novel therapeutic strategy for managing menopause-related metabolic diseases.
- Modulating FSH may offer a way to combat obesity and related complications in postmenopausal women.
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