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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
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Neurobrucellosis.

Na Zheng1, Wei Wang1, Jia-Tang Zhang1

  • 1a Department of Neurology , General Hospital of the People's Liberation Army , Beijing , China.

The International Journal of Neuroscience
|August 4, 2017
PubMed
Summary
This summary is machine-generated.

Neurobrucellosis (NB) is a rare complication of brucellosis. Early detection and treatment of NB are crucial for reducing mortality and long-term complications, especially in patients with autonomic dysfunction.

Keywords:
Neurobrucellosisclinical manifestationsimaging findingslaboratory findingstreatment

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Neurobrucellosis (NB) is an uncommon manifestation of brucellosis, characterized by diverse and often atypical clinical presentations.
  • Brucellosis can affect the central and peripheral nervous systems, leading to significant morbidity.

Purpose of the Study:

  • To analyze the demographic, clinical, laboratory, and imaging characteristics of patients with neurobrucellosis.
  • To evaluate treatment strategies and outcomes for neurobrucellosis patients.

Main Methods:

  • Retrospective review of data from 17 patients diagnosed with neurobrucellosis.
  • Data collected included patient demographics, clinical symptoms, laboratory test results (serum and CSF agglutination tests), imaging findings, treatments administered, and patient outcomes.

Main Results:

  • Fever (59%) and urinary/defecation disorders (53%) were common symptoms. Cranial nerve involvement was observed in 71% of patients.
  • Positive serum and cerebrospinal fluid agglutination tests were found in 88.2% and 59% of patients, respectively. Radiologic findings varied, including normal scans, white matter changes, vascular insults, and inflammatory changes.
  • Most patients (76%) were cured with a six-month antibiotic regimen (rifampicin, doxycycline, ceftriaxone sodium, sulphamethoxazole), but 24% experienced sequelae or were lost to follow-up.

Conclusions:

  • Neurobrucellosis should be considered in patients presenting with autonomic dysfunction, particularly urinary and defecation disorders.
  • Hearing loss due to vestibulocochlear nerve injury may be a characteristic symptom of NB. High rates of sequelae suggest the importance of early diagnosis and intervention.
  • Prompt detection, diagnosis, and treatment are essential to minimize mortality and long-term neurological deficits associated with neurobrucellosis.