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Updated: Feb 25, 2026
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Published on: February 9, 2021
Synthesis and Biological Evaluation of New Tacrine Analogues under Microwave Irradiation
Hossa Fahad Alshareef1, Heba Abd El Hady Mohamed1,2, Abdellatif Mohamed Salaheldin3
1Chemistry Department, Faculty of Applied Science, Umm Alqura University.
Abstract:
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe-Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedländer reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman's test on acetylcholinesterase inhibition.
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