Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Inhalation Exposure Method for Illegal Drugs.

Akiko Inomata¹, Akio Ogata¹, Yukie Tada¹

¹Tokyo Metropolitan Institute of Public Health.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan

|August 4, 2017

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Analysis of Angelica Root Marker Constituents and Furocoumarins in a Dietary Supplement Containing Angelica gigas by Liquid Chromatograph-Mass Spectrometer with a Photodiode Array Detector].

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·2026

Same author

Combined Effects of Dinotefuran and Piperonyl Butoxide on Behavioral Development in an F<sub>1</sub>-Generation Toxicity Study in Mice.

Birth defects research·2026

Same author

Predicting Anthracycline-Induced Cardiotoxicity Using the HFA-ICOS Risk Score: A Validation Study From AIC Registry.

JACC. Asia·2026

Same author

Clinical Characteristics and Outcomes of Heart Failure with Preserved Ejection Fraction Versus Reduced Ejection Fraction in Patients Receiving Anticancer Drugs.

Cardiovascular toxicology·2026

Same author

Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an F<sub>1</sub> Generation of Mice.

Birth defects research·2026

Same author

Assessment of μ-Opioid Receptor Signaling Responses for Fentanyl Analogs Using Luciferase Complementation Assay.

Biological & pharmaceutical bulletin·2025

A novel inhalation method effectively assesses synthetic cannabimimetics like AB-CHMINACA and 5F-AMB. This technique distinguishes drug effects from controls, aiding illegal drug analysis.

Area of Science:

Pharmacology
Toxicology
Drug Analysis

Background:

Synthetic cannabimimetics are unregulated, emerging drugs of abuse.
Assessing their pharmacological effects requires reliable exposure methods.

Purpose of the Study:

To develop and validate a new inhalation exposure method for evaluating synthetic cannabimimetics.
To assess the pharmacological effects of "SOUTOU" (containing AB-CHMINACA and 5F-AMB) using the developed method.

Main Methods:

Developed an inhalation system using cigarettes containing test drugs or controls (marshmallow leaves).
Exposed mice to smoke, followed by neurobehavioral and catalepsy tests.
Analyzed effluent air to assess drug decomposition.

Main Results:

Keywords:

inhalation exposure mouse neuro-behavioral observation synthetic cannabimimetics

Related Experiment Videos

Mice exposed to "SOUTOU" showed distinct excitement and suppressive behaviors indicative of cannabimimetic action.
Control mice exhibited transient, less pronounced suppressive behaviors.
The method differentiated drug-specific effects from control responses.

Conclusions:

The developed inhalation exposure method is effective for determining cannabinoid-specific pharmacological effects.
This method can assess the presence of active compounds in illicit drugs by comparison with controls.