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Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava
Shingen Nakamura1, Kumiko Kagawa1, Ryohei Sumitani1
1Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan.
Primary lymphoma of the superior vena cava is rare. A case of diffuse large B-cell lymphoma in the superior vena cava achieved complete remission with rituximab and R-CHOP chemotherapy.
Area of Science:
- Oncology
- Hematology
- Vascular Biology
Background:
- Primary lymphoma of the great veins, such as the superior vena cava (SVC), is exceptionally rare.
- Understanding the origins and behavior of intravascular lymphomas is crucial for effective treatment strategies.
Observation:
- A 70-year-old male presented with a computed tomography (CT) scan revealing a tumor confined to the SVC, causing complete occlusion.
- A transjugular biopsy confirmed the presence of diffuse large B-cell lymphoma (DLBCL), with tumor cells expressing CD30.
Findings:
- The patient received rituximab monotherapy followed by five cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy.
- A complete remission was achieved, with no evidence of recurrence observed two years post-treatment.
Implications:
- This case highlights a rare presentation of DLBCL originating within a large vein.
- The distinct pathophysiology of SVC lymphoma compared to intravascular large B-cell lymphoma (IVLBL) warrants further investigation.
- Successful treatment with rituximab-based regimens suggests a potential therapeutic approach for this rare entity.
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