Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma: non-responsiveness to conventional therapy.

A S Rebuck

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1986
    PubMed
    Summary

    Asthma management may require reassessment of adherence and allergen avoidance. Newer inhaled therapies, including combination treatments and liquid sodium cromoglycate, offer improved bronchodilation and potential steroid-sparing effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bronchoalveolar lavage.

    Canadian Medical Association journal·2010
    Same author

    Is the short-term response to inhaled beta-adrenergic agonist sensitive or specific for distinguishing between asthma and COPD?

    Chest·1994
    Same author

    Assessment of airway tone in asthma. Comparison between double lung transplant patients and healthy subjects.

    The American review of respiratory disease·1993
    Same author

    Tracheobronchial dilation during isocapnic hypoxia in conscious humans.

    Journal of applied physiology (Bethesda, Md. : 1985)·1993
    Same author

    Trends in asthma and chronic obstructive pulmonary disease therapy in Canada, 1985 to 1990.

    The Journal of allergy and clinical immunology·1993
    Same author

    Highlights of the nedocromil sodium clinical study presentations.

    The Journal of allergy and clinical immunology·1993

    Area of Science:

    • Pulmonology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Some asthma patients experience fluctuating peak flow despite standard treatments like beta-agonists, topical steroids, and theophylline.
    • Conventional corticosteroid therapy may offer limited improvement in severe or fluctuating asthma cases.

    Purpose of the Study:

    • To explore alternative and advanced therapeutic strategies for managing difficult-to-control asthma.
    • To evaluate newer inhalation methods and combination therapies for enhanced bronchodilation and reduced steroid dependence.

    Main Methods:

    • Review of current and emerging asthma treatment options, including nebulized medications and alternative corticosteroid administration routes.
    • Assessment of combination therapy efficacy (beta-agonist with ipratropium) and the role of sodium cromoglycate.
    • Evaluation of high-dose inhaled beclomethasone and intravenous methylprednisolone as alternatives to oral corticosteroids.

    Main Results:

    • Combination therapy with beta-agonists and ipratropium demonstrates superior bronchodilation compared to monotherapy.
    • Liquid sodium cromoglycate, when used regularly, may possess bronchodilator properties and a steroid-sparing effect.
    • High-dose inhaled beclomethasone and intravenous methylprednisolone offer intensified corticosteroid therapy options with potential benefits in lung permeability.

    Conclusions:

    • Optimizing adherence, allergen avoidance, and considering newer inhaled therapies are crucial for managing fluctuating asthma.
    • Combination nebulized therapies and sodium cromoglycate represent valuable additions to the asthma treatment armamentarium.
    • Intensified corticosteroid strategies, including high-dose inhaled or intravenous formulations, provide alternatives for managing severe inflammatory airway diseases.

    Related Experiment Videos