Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Airway inflammation and autonomic control.

P J Barnes

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1986
    PubMed
    Summary

    Autonomic nerves influence airway function, but their role in asthma is complex. While cholinergic reflexes may not be key, adrenergic and non-adrenergic, non-cholinergic pathways show altered function in asthma patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Glucocorticoid resistance in asthma.

    American journal of respiratory and critical care medicine·1995
    Same author

    Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.

    The Journal of experimental medicine·1995
    Same author

    Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

    Molecular pharmacology·1995
    Same author

    Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.

    The American journal of physiology·1995
    Same author

    Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.

    Thorax·1995

    Area of Science:

    • Respiratory Medicine
    • Autonomic Neuroscience
    • Pulmonology

    Background:

    • Autonomic nerves regulate airway functions like smooth muscle tone and mucus secretion.
    • Airway inflammation in asthma may lead to autonomic dysfunction.
    • Current understanding of autonomic nerve involvement in asthma pathophysiology is incomplete.

    Purpose of the Study:

    • To review the role of autonomic nerves in airway function and asthma.
    • To investigate potential abnormalities in cholinergic, adrenergic, and non-adrenergic, non-cholinergic systems in asthma.

    Main Methods:

    • Review of existing evidence on autonomic nerve function in asthma.
    • Analysis of the role of inflammatory mediators in modulating neural responses.
    • Examination of the effects of anticholinergic and adrenergic agents in asthma models.

    Main Results:

    • Cholinergic reflex bronchoconstriction may not be a major factor in clinical asthma.
    • Adrenergic abnormalities, including potentially impaired beta-receptor function and enhanced alpha-receptor activity, are observed.
    • Circulating adrenaline levels do not increase in asthmatic bronchoconstriction.
    • Non-adrenergic, non-cholinergic nerves represent the primary neural bronchodilator pathway.

    Conclusions:

    • Autonomic dysfunction, particularly involving adrenergic and non-adrenergic, non-cholinergic systems, likely contributes to asthma.
    • Further research is needed to identify the neurotransmitter in non-adrenergic, non-cholinergic nerves and its role in asthma.

    Related Experiment Videos