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LIPID PROFILE IN NORMAL HEALTHY CHILDREN

Vipan Chandar1, C H Gidvani2, A K Gupta3

  • 1Classified Specialist Pediatrics, 166 MH C/O 56 APO.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed

Insights

This study establishes normal lipid profiles in healthy children aged 0-12 years. Lipid levels, including total cholesterol, HDL, LDL, and triglycerides, increase significantly after birth, particularly in the first year.

Area of Science:

  • Pediatrics
  • Clinical Chemistry
  • Biochemistry

Background:

  • Establishing normative data for lipid profiles in pediatric populations is crucial for identifying dyslipidemia.
  • Previous studies may lack comprehensive age stratification or sufficient sample sizes.

Purpose of the Study:

  • To determine age- and sex-specific normal reference ranges for lipid profiles in healthy children aged 0-12 years.
  • To analyze the developmental trends of lipid parameters from birth through adolescence.

Main Methods:

  • A cross-sectional study involving 150 healthy children aged 0-12 years.
  • Participants were categorized into six age groups: newborns, 0-1, 1-4, 4-7, 7-10, and 10-12 years.
  • Lipid profile measurements included total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides.

Main Results:

  • Lipid levels were lowest at birth and increased significantly during the first year of life.
  • A slower but consistent rise in lipid fractions was observed throughout childhood up to 12 years.
  • No significant sex-based differences were found in lipid profile values across the studied age groups.

Conclusions:

  • The study provides essential reference ranges for pediatric lipid profiles, aiding in the early detection of lipid abnormalities.
  • Understanding the developmental trajectory of lipid metabolism in children is vital for long-term cardiovascular health assessment.

Keywords:
HDL cholesterolLDL cholesterolLipid profileTotal cholesterolTriglycerides

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