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VARIABLE RATE IV INFUSION OF MORPHINE AND HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION.

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Summary

Intravenous morphine infusion with diazepam effectively blunts the hemodynamic response to tracheal intubation. This combination proved superior to intramuscular morphine and diazepam for managing blood pressure and pulse rate during anesthesia.

Keywords:
Haemodynamic responseLaryngoscopyMorphineTracheal intubation

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Area of Science:

  • Anesthesiology
  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Laryngoscopy and tracheal intubation can provoke significant hemodynamic responses.
  • Managing these responses is crucial for patient safety during general anesthesia (GA).

Purpose of the Study:

  • To compare the efficacy of two different premedication regimens in attenuating the hemodynamic response to laryngoscopy and tracheal intubation.
  • To evaluate the impact of intravenous (IV) morphine infusion versus intramuscular (IM) morphine on hemodynamic stability.

Main Methods:

  • Two groups of 45 patients each were studied.
  • Group I received IV morphine infusion followed by IV diazepam.
  • Group II received IM morphine followed by IV diazepam; hemodynamic parameters were recorded post-intubation.

Main Results:

  • Group I showed no significant increase in pulse rate or systolic blood pressure (SBP) post-intubation, with only a transient increase in diastolic blood pressure (DBP).
  • Group II exhibited significant increases in pulse rate, SBP, and DBP up to 3 minutes post-intubation.
  • IV morphine infusion combined with IV diazepam was more effective in attenuating hemodynamic responses.

Conclusions:

  • Intravenous morphine infusion in combination with IV diazepam provides superior attenuation of hemodynamic responses to tracheal intubation compared to IM morphine premedication.
  • This regimen offers a safer approach to managing cardiovascular stress during airway manipulation in anesthesia.