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IN VITRO COMPARATIVE ACTIVITY OF EIGHT ANTIPSEUDOMONAL AGENTS
G S Chopra1, S S Gill2, S K Basu3
1Classified Specialist (Path), & OC, CPL (WC) Delhi Cantt - 110 010.
Abstract:
Five hundred and thirty strains of Pseudomonas aeruginosa isolated from indoor patients were tested against three chemical groups comprising eight antibiotics. High degree of resistant strains ranging from 38.0% to 61.8% were seen against carbenicillin, piperacillin and gentamicin. However amikacin, ciprofloxacin, ceftazidime, netilmicin and norfloxacin showed comparatively better activity with resistant strains ranging from 7.8% to 22.8%. A notably higher rate of resistance was seen in urinary isolates.
Insights
Pseudomonas aeruginosa strains show high resistance to common antibiotics like carbenicillin and gentamicin. However, newer antibiotics such as amikacin and ciprofloxacin demonstrate better efficacy, especially in urinary tract infections.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Pseudomonas aeruginosa is a significant opportunistic pathogen.
- Antimicrobial resistance in P. aeruginosa poses a major healthcare challenge.
- Monitoring antibiotic susceptibility is crucial for effective treatment.
Purpose of the Study:
- To assess the antibiotic susceptibility patterns of P. aeruginosa strains from indoor patients.
- To identify antibiotics with varying efficacy against P. aeruginosa.
- To highlight potential differences in resistance rates based on isolate source.
Main Methods:
- Testing 530 P. aeruginosa isolates from indoor patients.
- Evaluating susceptibility against eight different antibiotics across three chemical groups.
- Analyzing resistance rates for each antibiotic tested.
Main Results:
- High resistance rates (38.0%-61.8%) observed for carbenicillin, piperacillin, and gentamicin.
- Lower resistance rates (7.8%-22.8%) noted for amikacin, ciprofloxacin, ceftazidime, netilmicin, and norfloxacin.
- Urinary isolates exhibited a notably higher rate of resistance.
Conclusions:
- Significant resistance to older antibiotics necessitates careful selection of treatment.
- Amikacin, ciprofloxacin, and other newer agents show promise against P. aeruginosa.
- Urinary tract infections caused by P. aeruginosa may require specific antibiotic strategies due to higher resistance.
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