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Updated: Feb 25, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

ELECTRON MICROSCOPY IN LUPUS NEPHRITIS (A Case Report).

P Sivadas¹, Harsh Kumar², J R Bhardwaj³

¹Associate Professor, Department of Pathology, Armed Forces Medical College, Pune 411 040.

Medical Journal, Armed Forces India

|August 4, 2017

Summary

Electron microscopy is crucial for diagnosing lupus nephritis in pediatric patients when other tests are inconclusive. This technique revealed characteristic features, aiding in the diagnosis of this kidney condition.

Keywords:

Lupus nephritis Ultrastructure

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

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Published on: May 31, 2017

Area of Science:

Nephrology
Pediatric Nephrology
Electron Microscopy

Background:

Lupus nephritis diagnosis in children can be challenging.
Standard serological and histological methods may yield inconclusive results.

Observation:

An 8-year-old female presented with proteinuria and microscopic hematuria.
Initial renal needle biopsy and serological tests were non-diagnostic.

Findings:

Ultrastructural examination of the renal biopsy revealed distinct features consistent with lupus nephritis.
Electron microscopy proved essential in identifying the specific glomerular pathology.

Implications:

Highlights the diagnostic utility of electron microscopy in pediatric lupus nephritis.
Suggests incorporating ultrastructural studies earlier in diagnostic workups for suspected cases.
Emphasizes the role of advanced imaging in pediatric kidney disease diagnosis.