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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
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SUBACUTE SCLEROSING PANENCEPHALITIS (A Report on Two Cases).

Mkk Rao1, R K Gupta2, V C Ohri3

  • 1Reader Microbiology, Armed Forces Medical College, Pune - 40.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed
Summary

Subacute sclerosing panencephalitis (SSPE) is a rare neurological complication following measles infection. Diagnosis in these cases confirmed SSPE through specific antibody testing in cerebrospinal fluid and serum.

Keywords:
MeaslesSSPE

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disease.
  • It is a delayed complication of measles virus infection acquired in childhood.

Observation:

  • Two cases of SSPE were diagnosed.
  • Both patients had a history of measles infection during childhood.
  • Diagnostic criteria defined by Dyken were utilized.

Findings:

  • High titers of measles-specific antibodies were detected in the cerebrospinal fluid (CSF) and serum of both patients.
  • Quantitative ELISA confirmed elevated antibody levels.

Implications:

  • These findings reinforce the link between childhood measles infection and the development of SSPE.
  • Early diagnosis and understanding of SSPE pathogenesis are crucial for patient management.
  • The study highlights the importance of measles vaccination in preventing such neurological sequelae.