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SUBACUTE SCLEROSING PANENCEPHALITIS (A Report on Two Cases)
Abstract:
We report two cases of subacute sclerosing panencephalitis (SSPE) which is a rare, late neurological sequel, of measles infection acquired in childhood. The diagnosis was reached by adopting criteria defined by Dyken. Past history of measles was present in both the cases and they showed high titres of measles specific antibody in CSF and serum by quantitative ELISA.
Insights
Subacute sclerosing panencephalitis (SSPE) is a rare neurological complication following measles infection. Diagnosis in these cases confirmed SSPE through specific antibody testing in cerebrospinal fluid and serum.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disease.
- It is a delayed complication of measles virus infection acquired in childhood.
Observation:
- Two cases of SSPE were diagnosed.
- Both patients had a history of measles infection during childhood.
- Diagnostic criteria defined by Dyken were utilized.
Findings:
- High titers of measles-specific antibodies were detected in the cerebrospinal fluid (CSF) and serum of both patients.
- Quantitative ELISA confirmed elevated antibody levels.
Implications:
- These findings reinforce the link between childhood measles infection and the development of SSPE.
- Early diagnosis and understanding of SSPE pathogenesis are crucial for patient management.
- The study highlights the importance of measles vaccination in preventing such neurological sequelae.
