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STUDIES ON HBsAG IN HIV SEROPOSITIVE CASES.

P N Arora1, A L DAS2

  • 1Senior Adviser; (Derm and Ven), Command Hospital, Southern Command, Pune 411 040.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed
Summary
This summary is machine-generated.

Hepatitis B virus surface antigen (HBsAg) was found in 10.2% of patients with human immunodeficiency virus (HIV). Nearly half of these patients developed a chronic carrier state, highlighting a significant co-infection burden.

Keywords:
Acquired immunodeficiency syndromeHepatitis B virusHuman immunodeficiency virus

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Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Human immunodeficiency virus (HIV) infection is a global health concern.
  • Hepatitis B virus (HBV) co-infection is common in HIV-positive individuals.
  • Understanding the prevalence and outcomes of HBV in HIV patients is crucial for clinical management.

Purpose of the Study:

  • To determine the prevalence of hepatitis B virus surface antigen (HBsAg) in HIV-infected patients.
  • To assess the development of a chronic carrier state in HIV patients with HBsAg positivity.
  • To provide data on the clinical significance of HBV/HIV co-infection.

Main Methods:

  • Screening of 255 patients with HIV for HBsAg.
  • Follow-up of HBsAg-positive patients every 6 months.
  • Monitoring for the development of a carrier state.

Main Results:

  • 10.2% of HIV-seropositive patients screened were positive for HBsAg.
  • Among HBsAg-positive HIV patients, 47.6% developed a carrier state.
  • This indicates a substantial rate of HBV persistence in this population.

Conclusions:

  • A significant proportion of HIV patients harbor occult or active HBV infection.
  • The high rate of carrier state development underscores the need for vigilant monitoring and management of HBV in HIV co-infected individuals.
  • Early detection and intervention strategies are essential to mitigate long-term complications of HBV/HIV co-infection.