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CLINICO-PATHOLOGICAL CORRELATION IN NEONATAL AUTOPSIES.

Ts Raghu Raman1, Daljit Singh2, Y P Jalpota3

  • 1Associate Professor (Paediatrics), AFMC, Pune.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed
Summary

Autopsies on deceased neonates in intensive care revealed significant findings. Some autopsy results could have altered clinical management, potentially improving outcomes for critically ill infants.

Keywords:
AutopsyCause of deathPerinatal mortality

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Area of Science:

  • Neonatalogy
  • Pediatric Pathology
  • Intensive Care Medicine

Background:

  • Neonatal intensive care units (NICUs) manage critically ill newborns.
  • Mortality in NICUs necessitates understanding causes of death.
  • Autopsy plays a crucial role in verifying diagnoses and identifying unexpected findings.

Purpose of the Study:

  • To evaluate the impact of autopsy findings on clinical management in neonates.
  • To determine the discrepancy between antemortem diagnoses and autopsy results.
  • To identify potential missed opportunities for improved neonatal care.

Main Methods:

  • Retrospective review of 43 neonate deaths in an NICU (Jan 1991-Sep 1993).
  • Analysis of autopsy reports for 23 neonates (53% of deaths).
  • Comparison of antemortem diagnoses with major and minor autopsy findings.

Main Results:

  • Autopsy was performed in 53% of the 43 neonate deaths.
  • Six major autopsy findings could have altered clinical management and potentially improved survival.
  • Eight major findings would not have changed management, and 14 minor findings were unrelated to the primary cause of death.

Conclusions:

  • Autopsies in neonates can reveal critical information missed during clinical care.
  • Integrating autopsy findings into clinical practice may enhance management strategies for critically ill infants.
  • Further research is needed to optimize the utility of post-mortem examinations in neonatal intensive care.