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MicroRNA-based Regulation of Picornavirus Tropism
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MicroRNAs as Important Players in Host-Adenovirus Interactions
Diogo Piedade1, José M Azevedo-Pereira1
1Host-Pathogen Interaction Unit, iMed.ULisboa, Faculdade de Farmácia, Universidade de LisboaLisboa, Portugal.
Frontiers in Microbiology
|August 4, 2017
Summary
MicroRNAs (miRNAs) regulate gene expression and cellular processes. This review explores how viruses, like adenoviruses, interact with cellular miRNAs, impacting gene regulation and disease.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- MicroRNAs (miRNAs) are key regulators of gene expression involved in numerous cellular processes.
- Dysregulation of miRNAs is linked to various diseases.
- Viruses can interfere with cellular miRNA pathways to promote infection.
Purpose of the Study:
- To review the biogenesis and molecular interactions of miRNAs.
- To explain the basic concepts of miRNA functions.
- To examine the interplay between miRNAs and human adenoviruses.
Main Methods:
- Literature review of miRNA biogenesis and function.
- Analysis of viral mechanisms affecting cellular miRNAs.
- Focus on adenoviruses and their encoded viral-associated (VA) RNAs.
Main Results:
- Cellular miRNAs control hundreds of biological processes.
- Adenoviruses encode VA RNAs that can inhibit miRNA pathway proteins (Exportin-5, Dicer).
- Viral interference leads to significant changes in cellular miRNA profiles and functions.
Conclusions:
- miRNAs are crucial for cellular homeostasis and are implicated in disease.
- Adenoviruses utilize VA RNAs to manipulate host miRNA machinery for pathogenesis.
- Understanding these interactions is vital for comprehending viral infection and disease development.
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