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Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

John A L Meeuwsen1, Marian Wesseling1, Imo E Hoefer2

  • 1Laboratory for Experimental Cardiology, University Medical Center Utrecht, Utrecht, Netherlands.

Frontiers in Cardiovascular Medicine
|August 4, 2017
PubMed

Insights

Circulating inflammatory cells may serve as crucial biomarkers for predicting recurrent cardiovascular events in patients with atherosclerosis. Identifying high-risk individuals is key for improving secondary prevention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biomarker Discovery

Background:

  • Atherosclerosis is a chronic inflammatory disease causing most ischemic events like heart attack and stroke.
  • While survival rates have improved, 12% of patients experience recurrent events within six months.
  • Current risk prediction lacks routine biomarkers for identifying high-risk patients.

Purpose of the Study:

  • To review the evidence on circulating inflammatory cells as biomarkers.
  • To assess their potential for predicting recurrent adverse events in cardiovascular disease patients.

Main Methods:

  • Literature review of studies on inflammatory cells and cardiovascular events.
  • Analysis of current evidence regarding biomarker potential.

Main Results:

  • Inflammation plays a central role in atherosclerotic lesion progression and destabilization.
  • Circulating inflammatory cells are increasingly studied for their prognostic value.

Conclusions:

  • Circulating inflammatory cells show promise as biomarkers for risk stratification.
  • Further research is needed to establish their routine clinical utility in secondary prevention.

Keywords:
acute coronary syndromesbiomarkerscirculating cellscoronary artery diseasefollow-upinflammatory cellsstable coronary artery disease

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