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Updated: Feb 25, 2026

Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
The effects of metformin on gut microbiota and the immune system as research frontiers
1Division of Cancer Prevention, Department of Oncology, McGill University, Montreal, QC, H3T 1E2, Canada. michael.pollak@mcgill.ca.
Abstract:
Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has revealed complexity not previously appreciated, and opened new research directions. The extent to which immunomodulatory effects and actions on the microbiota are related to each other and account for effects on host energy metabolism remains to be determined. These sites of action may be relevant not only to the efficacy of metformin for its established use in type 2 diabetes, but also to proposed novel indications in oncology and other diseases.
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