Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recent advances in the detection and functional analysis of circRNAs with short-read RNA sequencing-based methods.

Molecular biology reports·2026

Same author

Utilisation of Machine Learning Approaches Improves RNA-Seq Transcriptome Analyses in Alzheimer's Disease Brain.

Journal of molecular neuroscience : MN·2026

Same author

Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease.

Molecular brain·2025

Same author

Computational methods for the analysis of long-read RNA-seq data.

Genomics·2025

Same author

Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study.

Acta neuropathologica·2025

Same author

Recent advances in investigation of circRNA/lncRNA-miRNA-mRNA networks through RNA sequencing data analysis.

Briefings in functional genomics·2025

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Purification of Transcripts and Metabolites from Drosophila Heads

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

Multiple System Atrophy: Many Lessons from the Transcriptome.

Ashton Curry-Hyde¹, Bei Jun Chen¹, Uwe Ueberham²

¹1 School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry

|August 4, 2017

Summary

This summary is machine-generated.

Multiple system atrophy (MSA) is a complex neurodegenerative disease. Understanding gene expression and transcriptome profiles can aid in faster diagnosis and improved quality of life for patients.

Keywords:

RNA sequencing alternative splicing human brain multiple system atrophy parkinsonism transcriptome α-synuclein

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: Feb 25, 2026

Purification of Transcripts and Metabolites from Drosophila Heads

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

Neurodegenerative diseases
Molecular pathology
Transcriptomics

Background:

Multiple system atrophy (MSA) is a debilitating neurodegenerative disease.
MSA is characterized by parkinsonism or cerebellar dysfunction and dysautonomia.
Current diagnosis is challenging, often requiring postmortem confirmation via α-synuclein aggregation.

Purpose of the Study:

To review advances in understanding the molecular pathology of MSA.
To focus on gene expression perturbations and the MSA transcriptome.
To explore potential for improved diagnosis and patient quality of life.

Main Methods:

Review of current literature on MSA molecular pathology.
Analysis of transcriptome profiling data in MSA.
Focus on individual gene expression changes.

Main Results:

Transcriptome profiling offers insights into the diseased state of MSA.
Understanding gene expression can contribute to identifying diagnostic markers.
The distinction between MSA subclasses (MSA-P and MSA-C) becomes less relevant as the disease progresses.

Conclusions:

There is currently no definitive in-vivo diagnostic method or cure for MSA.
Further research into MSA's molecular pathology, particularly gene expression, is crucial.
Advances in transcriptome analysis hold promise for earlier diagnosis and better patient care.