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Curve sketching is a systematic method for understanding the overall behavior of a function by analyzing its key mathematical features. A function defines a curve on the coordinate plane, where the horizontal axis represents the input variable and the vertical axis represents the output. The process begins by determining the domain, which specifies the set of input values for which the function is defined and establishes the horizontal extent of the graph.Intercepts with the horizontal and...
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PREPARE: guidelines for planning animal research and testing.

Adrian J Smith1, R Eddie Clutton2, Elliot Lilley3

  • 11 Norecopa, c/o Norwegian Veterinary Institute, P.O. Box 750, Sentrum, Oslo, Norway.

Laboratory Animals
|August 4, 2017
PubMed
Summary
This summary is machine-generated.

The PREPARE guidelines offer a framework for planning animal experiments to improve study quality and reproducibility. These recommendations cover formulation, inter-scientist communication, and quality control for better research outcomes.

Keywords:
animal experimentsanimal researchdesignguidelinesplanning

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Area of Science:

  • Laboratory animal science
  • Experimental design
  • Research integrity

Background:

  • Widespread concerns exist regarding the quality, reproducibility, and translatability of animal research.
  • Existing reporting guidelines inadequately address the crucial planning phase of animal experiments.

Purpose of the Study:

  • To introduce the PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) guidelines.
  • To provide overarching guidance for the planning stages of animal studies to enhance research quality.

Main Methods:

  • The PREPARE guidelines address three key areas: study formulation, dialogue between scientists and animal facilities, and quality control of experimental components.
  • A checklist is provided, adaptable for specific needs like field research.
  • Resources and advice are available on the Norecopa website.

Main Results:

  • The PREPARE guidelines offer a structured approach to planning animal experiments.
  • Implementation of PREPARE aims to improve the quality and reliability of animal study preparation.
  • The guidelines facilitate better communication and quality control in animal research planning.

Conclusions:

  • The PREPARE guidelines provide essential recommendations for planning animal experiments.
  • Adherence to PREPARE can significantly enhance the quality, reproducibility, and translatability of animal research.
  • These guidelines represent a crucial step towards improving the rigor of studies involving animals.