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A Microfluidic Biodisplay.

Francesca Volpetti1, Ekaterina Petrova1, Sebastian J Maerkl1

  • 1Institute of Bioengineering, School of Engineering, Ecole Polytechnique Federale de Lausanne , 1015 Lausanne, Switzerland.

ACS Synthetic Biology
|August 4, 2017
PubMed
Summary
This summary is machine-generated.

Engineered cells can now be safely deployed as biosensors using a novel microfluidic biodisplay. This device enables continuous monitoring and provides clear visual alerts for contaminants like arsenic.

Keywords:
arsenicbiodisplaycontinuous bacterial culturingenvironmental sensorheavy metal sensormicrofluidics

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Area of Science:

  • Synthetic Biology
  • Microfluidics
  • Biosensors

Background:

  • Engineered cells offer potential as biosensors but face deployment challenges due to practical and biosafety issues.
  • Existing biosensor systems often lack continuous monitoring capabilities and user-friendly interfaces.

Purpose of the Study:

  • To develop a microfluidic device as an interface for engineered cellular systems.
  • To create a practical and safe biodisplay for environmental monitoring.

Main Methods:

  • Designed and constructed a microfluidic biodisplay with 768 individually programmable biopixels.
  • Demonstrated multiplexed, continuous sampling capabilities.
  • Utilized engineered cells to detect sodium-arsenite in tap water.

Main Results:

  • The biodisplay detected sodium-arsenite at 10 μg/L using a fluorescent microscope.
  • Arsenic contamination was reported down to 20 μg/L with a visual "skull and crossbones" symbol.
  • The system prevented the release of biological or chemical materials, ensuring environmental safety.

Conclusions:

  • The microfluidic biodisplay provides a practical and safe interface for engineered cellular systems.
  • This technology enables continuous, multiplexed environmental monitoring.
  • The system offers a user-friendly and low-cost solution for detecting contaminants like arsenic.