Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

925
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
925
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Two-Dimensional Microscopy in Microbiology01:29

Two-Dimensional Microscopy in Microbiology

1.7K
Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs.

Nature structural & molecular biology·2026
Same author

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

Cancer discovery·2025
Same author

Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline.

Science advances·2025
Same author

Geometric Diagrams of Genomes: constructing a visual grammar for 3D genomics.

Genome biology·2025
Same author

Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells.

Life science alliance·2023
Same author

In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of <i>Klf4</i> in suppressing early leukemic transformation.

Genes & development·2022
Same journal

Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

FEBS letters·2026
Same journal

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

FEBS letters·2026
Same journal

Modelling stem cell differentiation related processes-A practical overview for biologists.

FEBS letters·2026
Same journal

Overlapping gut microbiome signatures in aging and disease are characterized by enrichment of medication-associated oral microbes in the gut.

FEBS letters·2026
Same journal

Csk binding to integrin β3 is regulated by tyrosine and threonine phosphorylation of β3.

FEBS letters·2026
Same journal

Mixed-class J-domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly.

FEBS letters·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

412.0K

Challenges for visualizing three-dimensional data in genomic browsers.

Mike Goodstadt1,2,3, Marc A Marti-Renom1,2,3,4

  • 1Structural Genomics Group, CNAG-CRG, The Barcelona Institute of Science and Technology (BIST), Spain.

FEBS Letters
|August 4, 2017
PubMed
Summary
This summary is machine-generated.

Genomic interactions reveal genome spatial organization crucial for cell function. New visualization methods are needed to display complex 3D chromatin structures beyond linear genome browsers.

Keywords:
FAIR principlesRICH visualizationgenome browsersmultiscalethree-dimensional data

More Related Videos

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.2K
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

3.8K

Related Experiment Videos

Last Updated: Feb 25, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

412.0K
Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.2K
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

3.8K

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Genomic interactions define genome spatial organization and play key roles in cell function.
  • Current genomic browsers display linear, sequential data, limiting analysis of complex 3D chromatin structures.
  • Analyzing large-scale, multiscale, and time-dependent genomic data requires advanced visualization techniques.

Purpose of the Study:

  • To outline current challenges in visualizing spatial genomic data within mainstream browsers.
  • To explore novel visualization techniques for addressing these challenges.
  • To define requirements for coherent visualization of novel spatial genomic data.

Main Methods:

  • Review of current mainstream genomic browser capabilities for displaying genomic interactions.
  • Exploration of emerging visualization techniques for 3D chromatin structures.
  • Definition of requirements for effective spatial genomic data visualization.

Main Results:

  • Mainstream browsers struggle with legibility and screen space for 2D matrices and 3D genome representations.
  • Novel visualization techniques are being explored to overcome limitations of linear, track-based displays.
  • A set of requirements for coherent visualization of spatial genomic data has been defined.

Conclusions:

  • Effective visualization of spatial genomic data is critical for understanding genome organization and function.
  • New approaches are needed to handle the complexity and scale of modern genomic interaction data.
  • The defined requirements pave the way for improved whole genome visualization tools.