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Wiring the Human Brain: A User's Handbook.

Raphael M Bendriem¹, M Elizabeth Ross¹

¹Feil Family Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY 10021, USA.

|August 4, 2017

Summary

The Deleted in Colorectal Cancer (DCC) receptor is key for connecting brain networks. DCC regulates how nerve cell connections (axons) cross the central nervous system, essential for brain function.

Area of Science:

Neuroscience
Molecular Biology
Developmental Biology

Background:

Brain function relies on intricate neuronal networks.
These networks enable complex processes like movement, sensation, cognition, and behavior.
Proper formation of neuronal connections, particularly axonal pathways, is critical for nervous system development and function.

Purpose of the Study:

To investigate the role of the Netrin receptor, Deleted in Colorectal Cancer (DCC), in regulating axonal pathfinding.
To provide evidence for DCC as a master regulator of axonal crossing in the human nervous system.
To elucidate the molecular mechanisms underlying DCC's function in neuronal connectivity.

Main Methods:

Analysis of recent human studies focusing on neuronal development.

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Examination of molecular pathways involving Netrin signaling and DCC.

Review of evidence demonstrating DCC's influence on axonal guidance across the neuraxis.

Main Results:

Evidence indicates that DCC acts as a master regulator of axonal crossing.
DCC's role is crucial throughout the entire neuraxis, from the brain to the spinal cord.
These findings highlight DCC's significance in establishing fundamental brain circuitry.

Conclusions:

The Deleted in Colorectal Cancer (DCC) receptor is a pivotal molecule in establishing neuronal connectivity.
DCC's function as a master regulator of axonal crossing is essential for normal brain development and function.
Further research into DCC signaling pathways could offer insights into neurological disorders.