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Aortic calcification as a predictor of cardiovascular mortality
Lancet (London, England)
|November 15, 1986
Summary
Aortic calcification, visible on X-rays, significantly increases cardiovascular disease (CVD) death risk in men over 45. Early detection of this atherosclerosis may prompt crucial interventions for existing CVD risk factors.
Area of Science:
- Cardiovascular Medicine
- Radiology
- Epidemiology
Background:
- Aortic calcification is frequently observed on prelumbar X-rays.
- Its association with cardiovascular disease (CVD) requires further investigation.
Purpose of the Study:
- To investigate the relationship between aortic calcification and CVD mortality.
- To assess the predictive value of aortic calcification for CVD events.
Main Methods:
- A prospective study involving 1359 men and 1598 women from 1975-1978.
- X-rays were used to assess aortic calcification.
- Follow-up for 9 years to record CVD deaths.
Main Results:
- Aortic calcification prevalence increased with age, reaching 45% in men and 75% in women.
- Aortic calcification was linked to a six-fold increased risk of CVD death in men aged 45.
- The risk associated with aortic calcification decreased by 6% per year of age over 45.
Conclusions:
- Aortic calcification is a significant predictor of CVD mortality in men.
- Atherosclerosis in non-coronary/cerebral vessels has predictive relevance for CVD death.
- Diagnosing aortic calcification highlights the need for intervention on existing CVD risk factors.