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HLA and tropical sprue.

R Menendez-Corrada, E Nettleship, E A Santiago-Delpin

    Lancet (London, England)
    |November 22, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This study found a strong genetic link between tropical sprue and specific human leukocyte antigen (HLA) types in Puerto Rican patients. The Aw-19 series, particularly Aw-31, showed a significant association, suggesting a potential marker for the disease.

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    Area of Science:

    • Immunogenetics
    • Gastroenterology
    • Tropical Medicine

    Background:

    • Tropical sprue is a malabsorptive condition prevalent in certain tropical regions.
    • The etiology of tropical sprue remains incompletely understood, with potential genetic and environmental factors involved.
    • Previous research has explored associations between tropical sprue and human leukocyte antigen (HLA) profiles.

    Purpose of the Study:

    • To investigate the association between HLA antigens and tropical sprue in a Puerto Rican cohort.
    • To identify specific HLA alleles that may be linked to the susceptibility or manifestation of tropical sprue.

    Main Methods:

    • Human leukocyte antigen (HLA) typing was performed on 27 Puerto Rican patients diagnosed with tropical sprue.
    • Diagnosis was confirmed by intestinal biopsy and clinical improvement following folic acid treatment.

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  • A microcytotoxicity assay was employed for HLA antigen determination.

    • Main Results:

    • A significant association was observed between tropical sprue and the presence of at least one antigen from the Aw-19 series (p = 10^-10).
    • The Aw-31 antigen showed the strongest association, with a relative risk of 10.6 (p = 1.2 x 10^-6).
    • No significant association was found with B-locus antigens or specific haplotypes, suggesting a marker association.

    Conclusions:

    • The findings indicate a strong genetic predisposition to tropical sprue in Puerto Ricans, linked to specific HLA-A antigens.
    • The association with HLA-Aw-31 suggests it may serve as a genetic marker for tropical sprue.
    • The lack of B-locus or haplotype association implies the link might be a marker association rather than a direct immune response mechanism.