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Updated: Feb 25, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help?
Avudaiappan Maran1, Michael J Yaszemski2, Ananiy Kohut3
1Department of Orthopedics, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA. maran.avudai@mayo.edu.
Abstract:
Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin's therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed.

