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Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
Published on: October 21, 2009
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Electrospun Scaffolds for Corneal Tissue Engineering: A Review
Bin Kong1,2, Shengli Mi3,4
1Biomanufacturing Engineering Laboratory, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. lingxue0313@163.com.
Materials (Basel, Switzerland)
|August 5, 2017
Summary
Electrospun nanofibrous scaffolds offer a promising solution for corneal tissue engineering due to their tunable properties. These advanced materials address the shortage of donor corneas and risks associated with traditional grafts.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Tissue Engineering
Background:
- Corneal diseases are a leading cause of vision loss, impacting millions worldwide.
- Shortages of donor corneas and risks of immune rejection necessitate alternative solutions.
- Corneal tissue engineering offers a viable strategy for creating corneal substitutes.
Purpose of the Study:
- To review advancements in electrospun scaffolds for corneal tissue engineering.
- To highlight the importance of scaffold properties for corneal regeneration.
- To discuss materials, structures, functionalization, and applications of these scaffolds.
Main Methods:
- Review of electrospun materials, including single and blended polymers.
- Analysis of scaffold fiber structures (isotropic and anisotropic).
- Examination of functionalization strategies for enhanced mechanical properties and transparency.
Main Results:
- Electrospinning enables fabrication of nanofibrous scaffolds mimicking native extracellular matrix (ECM).
- Scaffolds demonstrate high surface area-to-volume ratios and porosity.
- Tunable properties allow for suitable mechanical strength, transparency, and biological integration.
Conclusions:
- Electrospun scaffolds are crucial for developing effective corneal tissue substitutes.
- Scaffold design is paramount for successful corneal regeneration.
- Future research should focus on optimizing these scaffolds for clinical application.
