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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Polymeric Microneedle Array Fabrication by Photolithography
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Published on: November 17, 2015

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Microfabrication for Drug Delivery.

Brendan Koch1, Ilaria Rubino2, Fu-Shi Quan3

  • 1Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada. bmkoch@ualberta.ca.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Microfabrication technologies are revolutionizing drug delivery systems by enabling the creation of advanced, multifunctional devices. These methods offer cost-effective mass production and improved drug efficacy for various applications.

Keywords:
biocompatibilitydrug deliverymicrofabrication

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Area of Science:

  • Biotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Microfabrication technologies are increasingly vital in addressing challenges within life processes and pharmaceutical sciences.
  • Recent advancements focus on developing multifunctional and highly effective drug delivery systems using microfabrication.
  • Key advantages include mass production capabilities, high-quality control, cost-effectiveness, architectural design complexity, and material versatility.

Purpose of the Study:

  • To review the application of microfabrication technologies in developing advanced drug delivery systems.
  • To analyze silicon- and polymer-based fabrication methods for microfabricated drug delivery systems.
  • To discuss the biocompatibility of materials used in microfabrication and their role in drug delivery.

Main Methods:

  • Overview of silicon- and polymer-based microfabrication techniques.
  • Analysis of material biocompatibility studies relevant to microfabrication.
  • Review of applications in transdermal, oral, and implantable drug delivery systems.
  • Exploration of microfabricated vaccine delivery systems.

Main Results:

  • Microfabrication enables the production of complex, high-quality drug delivery systems.
  • Various fabrication methods (silicon- and polymer-based) are suitable for drug delivery applications.
  • Biocompatibility of materials is a critical consideration for successful microfabricated systems.
  • Applications span transdermal, oral, implantable, and vaccine delivery, enhancing stability and efficacy.

Conclusions:

  • Microfabrication provides innovative solutions for developing smart and advanced drug delivery systems.
  • These technologies are crucial for overcoming limitations in current drug delivery methods.
  • Future developments in microfabrication will continue to drive progress in pharmaceutical science and healthcare.