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Updated: Feb 25, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Strontium-Substituted Bioceramics Particles: A New Way to Modulate MCP-1 and Gro-α Production by Human Primary
Julien Braux1,2,3, Frédéric Velard4,5, Christine Guillaume6,7
1EA 4691 Biomatériaux et Inflammation en Site Osseux (BIOS), SFR CAP-Santé (FED 4231), University of Reims-Champagne-Ardenne, 1 Avenue du Maréchal Juin, 51095 Reims CEDEX, France. julien.braux@univ-reims.fr.
Background:
To avoid morbidity and limited availability associated with autografts, synthetic calcium phosphate (CaP) ceramics were extensively developed and used as bone filling materials. Controlling their induced-inflammatory response nevertheless remained a major concern. Strontium-containing CaP ceramics were recently demonstrated for impacting cytokines' secretion pattern of human primary monocytes. The present study focuses on the ability of strontium-containing CaP to control the human primary bone cell production of two major inflammatory and pro-osteoclastogenic mediators, namely MCP-1 and Gro-α, in response to ceramics particles.
Methods:
This in vitro study was performed using human primary osteoblasts in which their response to ceramics was evaluated by PCR arrays, antibody arrays were used for screening and real-time PCR and ELISA for more focused analyses.
Results:
Study of mRNA and protein expression highlights that human primary bone cells are able to produce these inflammatory mediators and reveal that the adjunction of CaP in the culture medium leads to their enhanced production. Importantly, the current work determines the down-regulating effect of strontium-substituted CaP on MCP-1 and Gro-α production.
Conclusion:
Our findings point out a new capability of strontium to modulate human primary bone cells' communication with the immune system.
