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Related Experiment Video

Updated: Feb 25, 2026

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Floating Hydrogel with Self-Generating Micro-Bubbles for Intravesical Instillation.

Tingsheng Lin1, Xiaozhi Zhao2, Yifan Zhang3

  • 1Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China. m18260087829@163.com.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel floating hydrogel with self-generating micro-bubbles for improved bladder drug delivery. This system prolongs drug residence time, enhancing therapeutic efficacy for bladder conditions.

Keywords:
acute bladder injuryfloating hydrogelintravesical instillationshakingthermo-sensitive hydrogel

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Urology

Background:

  • Intravesical instillation is a primary therapy for bladder cancer and interstitial cystitis.
  • Conventional drug delivery systems suffer from rapid elimination from the bladder post-instillation, limiting therapeutic effectiveness.
  • Existing hydrogels can cause bladder irritation and urinary obstruction.

Purpose of the Study:

  • To develop a novel floating hydrogel system with self-generating micro-bubbles for enhanced intravesical drug delivery.
  • To overcome the limitations of rapid drug clearance and potential side effects associated with traditional bladder therapies.
  • To improve drug residence time and therapeutic efficacy in the bladder.

Main Methods:

  • A floating hydrogel system utilizing the foamability of Poloxamer 407 (P407) was developed, generating micro-bubbles via simple shaking.
  • The hydrogel's ability to float and retain drug solution in urine was evaluated.
  • In vivo drug release studies were conducted over 10 hours, and efficacy was assessed using a rabbit acute bladder injury model with heparin treatment.

Main Results:

  • The P407-based hydrogel successfully formed stable micro-bubbles and floated in urine, mimicking clinical procedures.
  • Continuous drug release from the hydrogel was observed for 10 hours, significantly prolonging drug residence time in the bladder.
  • The enhanced drug residence time improved heparin's efficacy in protecting bladder mucosal permeability in a rabbit model.

Conclusions:

  • The developed floating hydrogel with self-generating micro-bubbles offers a single-component, easily prepared, and effective drug delivery system for intravesical therapy.
  • This innovative system enhances drug residence time and therapeutic outcomes, addressing safety and clinical efficiency concerns for bladder conditions.
  • The P407 hydrogel represents a promising advancement from bench to bedside for treating bladder diseases.