Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Somatostatin binding sites in human leptomeninx.

J C Reubi, R Maurer, S W Lamberts

    Neuroscience Letters
    |October 8, 1986
    PubMed
    Summary

    Specific somatostatin (SRIF) binding sites were found in the human leptomeninx. This discovery suggests somatostatin may play a role in meningeal physiology and related tumors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A rare case of a large spinal meningioma with mediastinal extension and malignant behavior classified histologically as benign.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2012
    Same author

    Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass.

    Diabetologia·2010
    Same author

    Biodistribution of two octreotate analogs radiolabeled with indium and yttrium in rats.

    Anticancer research·2010
    Same author

    Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial.

    European journal of nuclear medicine and molecular imaging·2010
    Same author

    Neuropeptide Y modulates steroid production of human adrenal H295R cells through Y1 receptors.

    Molecular and cellular endocrinology·2009
    Same author

    Glutamine as precursor for the GABA and glutamate trasmitter pools.

    Neuroscience letters·2009

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Histology

    Background:

    • Somatostatin (SRIF) is a peptide hormone with diverse physiological roles.
    • SRIF receptors are present in various tissues, including the brain and tumors.

    Purpose of the Study:

    • To investigate the presence and characteristics of somatostatin (SRIF) binding sites in the human leptomeninx.
    • To explore the potential role of SRIF in meningeal physiology.

    Main Methods:

    • Autoradiographical techniques were employed using a radiolabeled SRIF octapeptide analog (125I-204-090).
    • Competition assays with biologically active SRIF analogs were performed to confirm specificity.

    Main Results:

    • Specific somatostatin (SRIF) binding sites were successfully visualized in the human leptomeninx.
    • The density of these binding sites was comparable to that of the adjacent cortical tissue.
    • Binding was confirmed to be specific for SRIF, as only active analogs competed for the sites.

    Conclusions:

    • The human leptomeninx possesses specific somatostatin (SRIF) binding sites.
    • These findings, along with data from meningiomas, suggest a potential physiological role for SRIF in the leptomeninx.

    Related Experiment Videos