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Small airway bronchodilator response to different doses of salbutamol in 7-year-old children

Dong Keon Yon1, Hye Mi Jee1, Eun Kyo Ha1

  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.

Respiratory Research
|August 5, 2017
PubMed

Insights

The standard 400 μg salbutamol dose is more effective for bronchodilator response (BDR) testing in children, especially for assessing small airway reactivity. This finding aids in optimizing BDR testing protocols for pediatric asthma evaluations.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • Current Global Initiative for Asthma (GINA) guidelines lack specific bronchodilator ranges for bronchodilator response (BDR) testing, recommending a broad salbutamol dose of 200-400 μg.
  • This study investigated oscillometric BDR in children using low-dose (200 μg) versus standard-dose (400 μg) salbutamol.

Discussion:

  • Oscillometric reactance, indicative of small airway function, showed a significant dose-dependent association with salbutamol in children not meeting healthy control criteria.
  • The standard 400 μg dose demonstrated a more pronounced effect on small airway reactance compared to the 200 μg dose in this cohort.

Key Insights:

  • Salbutamol dose impacts oscillometric BDR results, particularly for small airway assessment.
  • A standard dose of 400 μg salbutamol is suggested for more sensitive oscillometric BDR testing in pediatric exclusion subjects.

Outlook:

  • Further research could refine optimal BDR testing protocols for pediatric respiratory conditions.
  • Standardizing BDR testing parameters may improve diagnostic accuracy and management of childhood asthma.

Keywords:
BronchodilatorChildrenSalbutamolSmall airway bronchodilator response

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