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[Effect of extensively hydrolyzed formula on growth and development of infants with very/extremely low birth weight]

Chun-Yan Gu1, Hui-Fen Jiang, Jin-Xiu Wang

  • 1Changzhou Maternal and Child Health Care Hospital, Changzhou, Jiangsu 213003, China. 1002451051@qq.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|August 5, 2017
PubMed

Insights

Extensively hydrolyzed formula improved feeding tolerance and growth in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. This specialized formula also reduced infection rates and promoted better gastrointestinal development.

Area of Science:

  • Neonatal Nutrition
  • Gastroenterology
  • Pediatric Growth and Development

Background:

  • Very low birth weight (VLBW) and extremely low birth weight (ELBW) infants often experience feeding intolerance and suboptimal growth.
  • Standard formulas may not always meet the specific nutritional and digestive needs of these vulnerable infants.

Purpose of the Study:

  • To evaluate the impact of extensively hydrolyzed formula on the growth, development, and gastrointestinal tolerance in VLBW and ELBW infants.
  • To compare outcomes between infants receiving extensively hydrolyzed formula and those receiving standard preterm formula.

Main Methods:

  • A randomized controlled trial involving 375 VLBW/ELBW infants, divided into an observation group (extensively hydrolyzed formula transitioning to standard) and a control group (standard formula).
  • Outcomes assessed included feeding intolerance, time to full enteral feeding, meconium excretion, bowel movements, growth parameters, motilin levels, and infection rates over 4 weeks.

Main Results:

  • The observation group showed significantly lower feeding intolerance, faster achievement of full enteral feeding, and quicker meconium excretion.
  • Infants on extensively hydrolyzed formula exhibited increased spontaneous bowel movements, enhanced weight, head circumference, and body length gain.
  • Higher motilin levels and a reduced incidence of infection were observed in the observation group compared to the control group.

Conclusions:

  • Extensively hydrolyzed formula positively influences motilin levels and gastrointestinal feeding tolerance in VLBW/ELBW infants.
  • This specialized formula supports improved early growth and development while concurrently decreasing infection rates.
  • The findings suggest extensively hydrolyzed formula is a beneficial nutritional strategy for VLBW and ELBW infants.
Abstract

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