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1Department of Radiology, First Affiliated Hospital of Nanjing Medical University, 300 Guang Zhou Road, Nanjing, 210029, Jiangsu Province, China.
Clinical Radiology
|August 5, 2017
Summary
Diffusion kurtosis imaging (DKI) and standard diffusion-weighted imaging (DWI) can differentiate endometrial carcinoma (EC) grades. DKI shows better performance than DWI in distinguishing high-grade from low-grade EC tumors.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Endometrial carcinoma (EC) grading is crucial for treatment planning.
- Accurate non-invasive methods are needed to differentiate tumor grades.
- Diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) are advanced MRI techniques.
Purpose of the Study:
- To assess the diagnostic accuracy of histogram analysis from DKI and DWI in distinguishing high-grade from low-grade EC.
- To compare the performance of DKI and DWI parameters in EC grading.
Main Methods:
- Seventy-three EC patients underwent 3T MRI.
- Apparent diffusion coefficient (ADC) from DWI, and Dapp and Kapp from DKI were analyzed.
- Entire-tumour histogram analysis and ROC curve analysis were performed.
Main Results:
- The 10th percentile of Dapp (AUC=0.821), 90th percentile of Kapp (AUC=0.891), and 10th percentile of ADC (AUC=0.801) showed diagnostic value.
- Combining 10th percentile Dapp and 90th percentile Kapp yielded the highest AUC (0.901).
- DKI parameters demonstrated superior performance compared to ADC in differentiating EC grades.
Conclusions:
- Entire-tumour histogram analysis of DKI and DWI is effective for grading EC.
- DKI offers better discrimination between high-grade and low-grade EC compared to standard DWI.
