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Related Concept Videos

Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Overview of Secretory Vesicles01:33

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Synaptic Signaling01:12

Synaptic Signaling

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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Synaptic Signaling01:09

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
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Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Related Experiment Video

Updated: Feb 25, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
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Synaptic vesicle 2C and its synaptic-related function.

Yan-Wei Hu1, Lei Xiao1, Lei Zheng1

  • 1Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Synaptic vesicle 2 C (SV2C) is a newly identified protein regulating neurotransmission and dopamine release, offering a potential therapeutic target for psychosis. SV2C also impacts hypertension and blood clotting, indicating broader disease relevance.

Keywords:
BoNT/AHypertensionPsychosesSV2CVTE and coagulation pathways

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Synaptic vesicle 2 C (SV2C) is a novel isoform within the SV2 protein superfamily.
  • SV2 proteins are crucial for vesicle trafficking, exocytosis, and neurotransmission.

Purpose of the Study:

  • To review the current understanding of SV2C's structure, distribution, function, and regulation.
  • To highlight SV2C's potential as a therapeutic target for various diseases.

Main Methods:

  • Literature review of existing research on SV2C.
  • Analysis of SV2C's role in neurological and non-neurological pathways.

Main Results:

  • SV2C is expressed in older brain regions and acts as a receptor for botulinum neurotoxin/A (BoNT/A).
  • SV2C regulates dopamine release and glucose-evoked granule recruitment, relevant to psychosis.
  • SV2C influences hypertension, venous thromboembolism (VTE), and coagulation, and is modulated by alendronate and statins.

Conclusions:

  • SV2C is a multifaceted protein with implications for neurological disorders like psychosis.
  • Emerging evidence suggests SV2C's involvement in cardiovascular and coagulation pathways.
  • Further research into SV2C's mechanisms may yield novel therapeutic strategies.